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Surgical mortality A large systematic review examined the use of antioxidant treatments, including NAC, on mortality and other global adverse events [29]

4.8 Ferroptosis in periventricular leukomalacia Periventricular leukomalacia (PVL) is a secondary white matter disorder predominantly affecting preterm infants, presenting clinically with bilateral spastic paresis, tetraplegia, and cognitive impairment (393, 394)

The radius of gyration (Rg), the root mean square deviation (RMSD) of the protein backbone and ligand, the minimum distance between the ligand and protein, and the Root Mean Square Fluctuations (RMSF) of residues near the ligand (within 5 Angstroms) were used to analyze these MD trajectories

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This reaction is catalyzed in a reverse direction by isocitrate dehydrogenase (IDH1/2), primarily in the cytosol or mitochondria, and becomes prominent when oxidative metabolism is constrained