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doi: 10.1161/01.CIR.94.1.6

10.1074/jbc.M210545200 J

Our team has found that the route decision matters less for total absorption and more for matching the kinetic profile to the intended therapeutic window

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Further, while the mucolytic properties of NAC [85] may provide benefit to patients with chronic bronchitis, bronchiectasis or disorders of mucus clearance, particularly if prolonged mechanical ventilation is anticipated, this must be balanced with the potential for bronchospasm as discussed below

Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)