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Treatment with pemetrexed continued until RECIST v1.1 (modified to follow a maximum of 10 target lesions and a maximum of 5 target lesions per organ)-defined progression of disease as determined by the investigator or unacceptable toxicity

When it is absent, the entire orchestra can fall out of tune

The core chelation site relies on the imidazole ring of histidine and the side chain amino group of lysine to ensure the controlled release of copper ions

Additionally, radiation-induced damage is amplified by the generation of reactive oxygen species (ROS), chemically reactive entities capable of oxidizing proteins and lipids and inducing single-strand DNA breaks (indirect effects)

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