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Mol Aspects Med (2019) 69:29

A previous study supported this, showing that treatment of SLC1A5 -knockdown HNSCC cell lines with V-9302 led to marked inhibition of glutamine metabolism, thereby suppressing growth and proliferation both in vitro and in vivo 97

It is difficult to judge for sure whether the early drastic decrease in Plp- and Mog- positive cells implies a drastic death/loss of the mature OLs or just an extreme-down regulation of the expression of these myelin-associated genes by the OLs while they themselves are still alive

In cell-based assays, ARA-290 is applied to cultured neuronal cell lines, primary Schwann cells, and pancreatic islet preparations to study receptor binding kinetics and intracellular signaling responses including STAT3 and NF-kB pathway modulation

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