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GA KK01.1.1.01.0007 funded by the European Union through the European Regional Development Fund)

In contrast, there are several synthetic analogs (such as Derivative 9, Figure 2I) showing better activity than alantolactone (LC 50 = 36.2 g/mL) (Cantrell et al., 2010)

Vaccine 24 , 10281034 (2006)

Figure 5 Proof of concept experiments that support the hypothesis of chronic glutamate toxicity in neurodegeneration As EAATs have been found to be down-regulated in many diseases of the nervous system (Sheldon and Robinson, 2007) and hypothetically increased L-glu and L-asp clearance should dampen the excitotoxic component of these diseases, many researchers have set out to identify compounds that induce EAAT2, which is the principal EAAT in the brain and most frequently found to be downregulated (Sheldon and Robinson, 2007

This blog covers the importance of assessing the 2OH/4OH and 2OH/16OH ratios and provides potential support considerations for suboptimal ratios from a functional medicine perspective