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Key inflammatory mediators implicated in its pathogenesis include interleukin (IL)17, IL-23, and tumor necrosis factor-alpha (TNF-), primarily released by activated dendritic cells and T-cells (Q

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In summary, depression remodels host lipid metabolism via TLR/PPAR- signaling and PUFA dysregulation, fostering an intracellular niche for Mtb survival while impairing anti-mycobacterial immunity