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It has the longest clinical track record of this group, used in parts of Europe and Asia for cognitive decline, mild cognitive impairment, and stroke recovery, with trials reporting cognitive benefit in impaired populations.9 Note the population: the case for Cerebrolysin is strongest in deficit states, which is consistent with Giurgea's original observation that nootropic effects show up most clearly under disturbed neural metabolism aging, hypoxia, injury rather than in an already-optimized 30-year-old

Estrogen therapy is known to have a protective role against neurodevelopmental disorders and glutamate-induced neurotoxicity via the mTOR pathway [125]

Much of the evidence comes from laboratory and animal studies, so benefits in humans are not guaranteed

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