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Description

Reddi AR, Culotta VC

Overall, limited studies investigated the improvement of pharmacological efficacy in animal models after dosing of the derivative (Table II)

H.NguyenL.DUC.LiuM.et al (2013)

The compound was first reported in Al-Obeidi, Castrucci, Hadley, and Hruby, J Med Chem 32 (12):255561 (1989) (PMID 2555512), building on the earlier open-chain superpotent precursor [Nle, D-Phe]--MSH reported by Sawyer, Sanfilippo, Hruby, Engel, Heward, Burnett, and Hadley in PNAS 77 (10):57548 (1980) (PMID 6777774)