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Description

Klotho The antiaging protein -Klotho is a 130 kDa membrane-bound protein mainly synthesized in the kidneys and acting as a coreceptor for FGF23, thereby mediating its renal effects with respect to phosphate handling and calcitriol synthesis [80]

Additionally, it may have potentially lowered the expression of urea cycle enzymes, restored nitrogen balance, and hypothetically normalized or improved the nitrogen contents in organs

Transient hunger: Mild and usually manageable

The convenience of oral dosing comes with a generally heavier side effect burden

This remains preliminary, but it aligns with broader evidence linking GH-IGF-1 signalling to neurological health in ageing populations

Therefore, additional research on the use of antifibrotics in IPF patients with CKD is needed to expand the treatment opportunities for IPF patients with CKD