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Mol Biol Cell (2003) 14(4):144859.10.1091/mbc.E02-06-0342 82 UngureanuDWuJPekkalaTNiranjanYYoungCJensenONet alThe pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

Theres no direct causal relationship

[1] Renal function should be monitored if significant gastrointestinal symptoms or dehydration occur

It's the difference between reproducible results and failed experiments