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Exp Mol Med (2026)

S., Poudevigne, A

This advantage cannot be found in any other model

M.HemeidaR

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Therefore, scientists devised an alternative by replacing all of the L-type amino acids in the FOXO4 short peptide with D-type amino acids, which inverts the conformation of FOXO4-Dri and competitively binds to p53, while preventing FOX04 from binding to p53