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Long-term exposure studies extending to 90 days report no mortality or severe adverse events but highlight the necessity to monitor for possible bioaccumulation and subtle organ function alterations in chronic use (Noga et al., 2023)

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Although the drugs given orally like theophylline and prednisolone, showed significant side effects in many patients, due to narrow therapeutic window and substantial morbidity limits its place in treatment (Cutroneo et al., 2022)