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The use of more complex techniques as the one-path and the two-path impedance spectroscopy is able to measure the two components of the R epi , the R para and the R trans (R epi = R para + R trans ) on top of the R bas ( Importantly, TEER does not discriminate between the above-mentioned pore and leak pathways since an increased permeability of both pathways will reduce TEER

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HIFs play a central role in adaptive regulation of energy metabolism under hypoxic conditions, facilitating the conversion from mitochondrial oxidative phosphorylation to glycolysis