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NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients

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Oocyte quality markedly decreased after acute exposure to H 2 O 2 and 4-HNE To further investigate the consequences of acute H 2 O 2 and 4-HNE exposure on oocyte quality we next assessed the integrity of the MII spindle, as a surrogate measure of embryonic potential 70 , and noted a dose-dependent decrease in the percent of normal spindles