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Firstly, observations in aged mice (2024-months-old) reveal morphological changes in astrocytes and alterations in territorial domain that may result in reduced contacts between adjacent astrocytes, disconnecting them from the greater pan-glial network which is essential for many homeostatic functions (e.g., K + spatial buffering, metabolic and cholesterol supply to oligodendrocytes

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The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

Inflammation is the body's natural response to injury or tissue damage

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