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Next, we attempted to identify the key genes related to T cells by clustering the single-cell sequencing dataset CNP0001102 into five T cell subpopulations and intersecting the differentially expressed genes in the GSE101702 dataset and the key modules in the WGCNA with each subpopulation

Furthermore, transfection of SH-SY5Y cells with siRNA targeting Rab7a (~ 5076% knockdown efficiency), followed by an incubation with 10% FCS and U18666A (2 g/ml) 50 M compound 10 , strongly reduced the ability of compound 10 to decrease cholesterol accummulation in Rab7-depleted SH-SY5Y cells (Fig

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YQ: Investigation, Writing review & editing