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10.1002/bies.950150206 Bioessays 17 BoccaccioC.AndM.TamagnoneL.BardelliA.MichieliP.BattistiniC.et al (1998)

The geroscience hypothesis proposes this principle but necessitates experimental testing

5-amino-1MQ showed concentration-dependent inhibition of NNMT in fully differentiated adipocytes that could be fit to a 3-parameter sigmoidal dose-response curve with a calculated EC50=2.3+/1.1 M (permeable NNMT inhibitorFIGS