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These oxygen derivatives have the capacity to restrict bacterial growth during tissue infections, as they can diffuse through the membranes of both intracellular and extracellular bacterial pathogens and damage their DNA, protein, and lipid molecules

A typical approach: 12 weeks on, 46 weeks off to allow GH receptor sensitivity and insulin sensitivity to normalize before beginning a subsequent cycle

However, a recent study demonstrated that mild UPRmt activation can extend lifespan, whereas strong activation has the opposite effect (Di Pede et al, 2025)