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AOD-9604 is a modified fragment of human growth hormone (specifically amino acids 176-191) that has been engineered to target fat metabolism without affecting growth hormone levels or insulin sensitivity

NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

Demonstrated that administration of NMN, an NAD + precursor, markedly reduced subcutaneous fat mass in mice fed a high-fat diet (HFD)

High-purity, research-grade formulation

No placebo-controlled human trial was identified for weight management, diabetes, fatty liver disease, sarcopenia, athletic performance or healthy ageing

As shown in Table 1 and Figure 6, the small molecule inhibitors targeting NNMT can be categorized into SAM-competitive inhibitors, NAM-competitive inhibitors, Dual-substrate-competitive inhibitors and isomerization inhibitors