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190 These vulnerabilities are particularly pronounced in the dopaminergic neurons of the substantia nigra due to their high metabolic demand and reliance on mitochondrial function

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When combined with Ipamorelin in dual-pathway research models, the two compounds engage both the cAMP pathway via GHRHR and the calcium signalling pathway via GHS-R1a simultaneously on the same somatotroph cell population producing a synergistic GH pulsatility profile that neither compound achieves independently