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Second, research in this field is highly heterogeneous and predominantly observational in nature

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Acute Effects of Various Doses of Nitrate-Rich Beetroot Juice on High-Intensity Interval Exercise Responses in Women: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial

This fragmentation contributes to the broader, well-recognized challenge of high attrition from preclinical signals to clinical benefit, particularly in chronic, heterogeneous conditions where species differences, comorbidities, and polypharmacy complicate external validity (Ineichen et al., 2024)

Next, the protein expression levels of ferroptosis-related factors were assessed through western blotting

A recent Korean study by Park JG et al found that intra-articular hyaluronic acid injections were associated with significant delay in total knee arthroplasty among patients with knee osteoarthritis