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Thus, the GLP-1 WT albiglutide-mimic and GLP-1 QMP fusions engaged the human GLP-1R expressed by the cells, although at a lower potency than unfused GLP-1, which is in line with previous reports on albiglutide/Tanzeum and other GLP-1 fusion proteins 10,76,77

Warner, M.L

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Deamidation of N 392 reveals only one peak and one product, which is consistent with the work of Robinson and Robinson that proposes that asparagine deamidates mainly by hydrolysis forming only aspartic acid unless it is followed by a glycine on the C-terminus side