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Although neuroendocrine features, Rb and p53 mutations are common, the current lack of actionable biomarkers has made it difficult to develop more effective treatments

Interestingly, mutating the KEAP1 sensor cysteine 151 to serine (C151S) reduced labeling, indicating that AA147 preferentially targets this cysteine to activate NRF2

Science 281 , 16741677 (1998)

Im not sure why but I think its a linking issue