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Description

Pharmacological agents Experimental design 29 III) Cancer group: subcutaneously (s.c) inoculated with 2 x 10 4 MAT-LyLu cells only, IV) Diabetic + cancer (DC) group: inoculated with 2 x 10 4 MAT-LyLu cells and STZ injection, V) Cancer + metformin (CM) group: injected with metformin 30 for 14 days after Mat-LyLu cells application VI) Diabetic + cancer + metformin (DCM) group: metformin administered for 14 days together with STZ and Mat-LyLu cells

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Semaglutide Semaglutide is a glucagon-like peptide-1 (GLP-1) used as a once-weekly injectable to treat type 2 diabetes and for long-term weight management

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The samples were prepared and analysed by LC-MS at Duke University as previously described 55

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The morphological features of ferroptosis are quite specific, including a reduction (disappearance) of the mitochondrial cristae, rupture of the outer mitochondrial membrane, wrinkling, darkening of the mitochondria, iron-dependent nuclei without rupture, and cell membrane rupture

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