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10.1080/08923973.2023.2165943 102 WangL.ChenY.MiY.QiaoJ.JinH.LiJ.et al (2021)

Targeting immunosenescence for improved tumor immunotherapy

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4.3 N-terminal domain The first 18 amino acids at the N-terminus of human ApoE protein serve as the signal peptide sequence that functions to direct newly synthesized ApoE to the Golgi apparatus for PTMs such as glycosylation and sialylation, and it gets cleaved before secretion of mature ApoE (Rall et al., 1982b