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Annu Rev Biochem 86(1):357386

Ergothioneine and resveratrol support antioxidative capacity via complementary pathways

Glutathione is often called the "master antioxidant" - not because it is the most potent single antioxidant, but because it: 1.Directly neutralizes reactive oxygen species (ROS) and reactive nitrogen species (RNS) 2.Regenerates other antioxidants - including vitamins C and E - after they have been oxidized 3.Powers the glutathione peroxidase (GPx) enzyme family - the enzymes most critical for neutralizing HO in the thyroid 4.Supports immune regulation - modulating T-cell and B-cell function, directly relevant to autoimmune thyroid disease 5.Facilitates detoxification - conjugating and eliminating environmental toxins (heavy metals, pesticides) that are known thyroid disruptors Pure Glutathione Powder - the supplemental form used in nutraceutical formulations - is typically produced through yeast fermentation (the cleanest, most bioavailable production method) and is available in reduced (L-glutathione, GSH) and oxidized (GSSG) forms

PMID: 17426848

At the same time oxidative stress caused downregulation of the cell cycle inhibitor p27 KIP1

Huang W, Li X, Yang H, Huang H