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The treatment group showed significant reductions in body weight (approximately 5% loss) and white adipose tissue mass (35% reduction) compared to control animals, despite no changes in food intake

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this is a maximum hypersensitivity reaction of the immune system with varying degrees of severity, but which can be acutely life-threatening (Bilwani et al., 2005)

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Briefly, the rat was suspended by the tail, and the maximum of toe spread in the injured hind limb was assessed when the rat was trying to escape, by counting the number of toes with visible abduction and separation from adjacent toes