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Several amino acids such as lysine, isoleucine, phenylalanine, histidine, and tyrosine significantly increase kidney arginase activity (Austic and Nesheim, 1970) while glycine and threonine suppress kidney arginase activity (Austic and Nesheim, 1970)

While the clinical significance of this in healthy adults is still being characterised, the theoretical concern about sustained supraphysiological IGF-1 and long-term tissue effects is the basis for the oncogenic risk concerns flagged in the long-term safety literature

doi: 10.3390/ijms24032671 70 LeemansMCouderqSDemeneix B and FiniJ-B

Cell 66 , 154162.e10 (2017)

And then there are the potential side effects of these peptide treatments, which can include everything from hormonal imbalances to injection-site reactions, fatigue, or even cardiovascular changes

Modulation by ozone therapy of oxidative stress in chemotherapy-induced peripheral neuropathy: the background for a randomized clinical trial