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These splenorenal APSC are thought to prevent the spleen from undergoing congestion, 17 which is why splenomegaly is not a feature of canine pre- and intrahepatic portal hypertensive disorders

Skin of face, arms, legs, and hands approaching normal

Doering, Faculty of Health Sciences, Department of Pathology and Molecular Medicine, McMaster University, HSC 1R1, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada e-mail: [email protected] This article was submitted to the journal Frontiers in Cellular Neuroscience