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However, when emodin, rhein and to a lesser extent cis -stilbene, were used in combination with each topoisomerase II inhibitor, there was an antagonistic increase in ATP, an inhibition of apoptosis and no cell-cycle arrest

G., & Coombes, J

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18.,19 Zinc Zinc is the second most abundant trace mineral, is required by more than 300 enzymes, and binds to over 2500 proteins approximately 10 percent of all human proteins

Obesity contributes to all components of metabolic syndrome, especially in the presence of excess abdominal fat (Batsis, Nieto-Martinez, & Lopez-Jimenez, 2007)