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Numerous studies today have found or demonstrated that the gut microbiota is inextricably linked to the development of autoimmune diseases (Zou et al., 2022), based on the current available knowledge we can propose a new model that illustrates the potential specific mechanisms by which the gut microbiota and its metabolites influence the pathogenesis and development of ITP, such as alteration of gut microbiota metabolites, imbalance of gut immune homeostasis, increased gut barrier permeability, gut microbiota translocation, etc

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