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POI is selected from a bioactive peptide, an enzyme, an enzyme inhibitor, an enzymatic catalytic site, a DNA-binding protein, an isolated protein domain, a ligand for receptors, a receptor, a growth factor, a cytokine, an antibody, an antibody fragment, an epitope, an epitope-binding region, an antigen, an allergen, and contiguous or overlapping fragments of a protein sequence of interest

In non-small cell lung carcinoma, there are varying levels of FOXO4 expressed that correspond to how the cancer was staged

Treatment of DIO mice with PYYMK-801 and GIPMK-801 did not affect body weight or food intake beyond that of the parent peptide analogues (Extended Data Fig

This progress remarkably extends the diseases that can be treated by RNAi therapeutics

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