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In two pivotal phase III trials (NCT00420212 and NCT00451451), dimethyl fumarate (DMF, 240 mg twice daily) significantly reduced the annualized relapse rate, MRI lesion activity, and disability progression relative to placebo, with a safety profile dominated by transient flushing and gastrointestinal symptoms

For instance, PS-NPs induce enrichment of Fusobacteria and Proteobacteria, concomitant with dysregulation of SCFA metabolism 36

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Aleem A.A., Samad A.B., Slenker A.K