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Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug

mTORC1 bi-steric treatment of the RP/MRD cell lines combined with either an SWI/SNF inhibitor or an inhibitor of OXPHOS showed a strong synergistic effect, inducing cuproptosis and cell death

For instance, a study employing mass spectrometry imaging found significant differences in metabolite distribution in the cerebellar cortex, prefrontal cortex, and hippocampus of depression model mice

86 Also, in an animal model of early Parkinsons disease, long-term KD seemed to be insufficient for the neuroprotective effect

After 68 h of fasting, the body produces -hydroxybutyrate, a ketone body that reduces inflammation and oxidative stress by increasing antioxidant enzyme activity and improving mitochondrial function [86,87]

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