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While Huntingtons disease is widely considered to be due to a gain-of-function toxic effect, it has been demonstrated through selective deletion of Htt in striatal projection neurons of mice that these neurons require Htt for motor regulation, synaptic development, cell health, and survival during aging ( Free copper enhances the aggregational toxicity of Htt (Lobato et al., 2024)

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This therapy leverages the regenerative properties of placental cells, which are rich in growth factors, cytokines, and nutrients

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When comparing control and H

Circular RNA, as an emerging non-coding RNA, is also involved in ferroptosis-related processes ( Table 1 )