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found activation of the polyol pathway and an upregulation of PARP-1 in the lungs of diabetic rats compared with nondiabetic animals, which correlated with increases in the NADH/NAD + ratio, the activities of mitochondrial respiratory complex IIV, and cellular ROS production (104), supporting the view that reductive stress occurs in the development of diabetic complications

School of Engineering Ella Rhuems, Pittsburg, Kansas

Additionally, a holistic approach to weight management, including diet and exercise, should be considered alongside medication when seeking sustainable weight loss

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R., Busby-Whitehead, J., Tsiao, C., Stewart, K