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HO-1 induction and heme degradation products exhibit various cytoprotective mechanisms (68)

The overexpression of GCH1 was confirmed to confer potent protection against ferroptosis induced by GPX depletion, IKE, and RSL3 (94)

Nevertheless, the concept and definition of intestinal permeability is relatively broad and includes not only an altered paracellular route, regulated by tight junction proteins, but also the transcellular route involving membrane transporters and channels, and endocytic mechanisms