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However, a real integrative strategy has been the focus of some recent investigations

Honaker 2008, Hauge 2011 ): avoidance of caffeine, nicotine, red wine, and other migraine triggers stress reduction (see the Stress Management protocol) improving sleep hygiene (see the Insomnia protocol) massage therapy chiropractic manipulation acupuncture getting sufficient exercise and frequent stretching 8 Dietary Interventions A significant association between dietary intake and migraine incidence exists

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Parsons CL, Zupkas P, Proctor J et al: Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis

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With respect to implications for treatment, serotonergic agents have multiple relevant therapeutic mechanisms, including blocking tau and A and promoting synaptic plasticity