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In contrast with adaptive memory, which lies on the gene recombination of antigen receptors and proliferation of specific lymphocyte clones, TI is triggered by the interplay between pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) and pattern recognition receptors (PRRs) on the innate immune cells, followed by long-term metabolic and epigenetic changes (99, 100) ( Figures 2 , 3 )

Although arachidonic acid mobilization and reactive oxygen species generation are well-known and well-studied components of innate immune responses, there are a dearth of studies characterizing the role of 4-HNE during infectious disease

Hou X, Shi X, Zhang W, Li D, Hu L, Yang J, et al

The path from interesting preclinical research to FDA approval is long, expensive, and requires showing safety and efficacy in human trials

Its lack can cause bleeding issues

2017;114:E3110-8 National Academy of Sciences