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If this holds true, then UA-lowering drugs may be helpful in prevention/management of diabetes, at least in subjects who are at risk for both hyperuricemia and diabetes

10.1056/NEJMoa2201737 103 RicheldiL.du BoisR

Tyrosinase is an enzyme that catalyzes the biosynthesis of melanin which is the culprit for skin darkening

Calcium channel Calcium is a critical regulator of cardiac function by maintaining cardiac excitation-contraction coupling, and disturbances in cardiac calcium regulation are a major contributor to left ventricular dysfunction in iron overload cardiomyopathy ( 2+ channels participate in iron uptake into cardiomyocytes (61)

However, after surgical removal of the ovaries, the production of these hormones stops completely, which can contribute to additional symptoms like decreased sex drive and fatigue

References Phipps EA, Thadhani R, Benzing T, Karumanchi SA