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Normal cells typically regulate cholesterol levels through SREBP2 [42], but tumor cells may have lost this self-regulation mechanism

Some individuals utilise them as a form of protection rather than as a substitute for a nutritious diet (Cox & Phelan, 2008) (Table 1)

Research from the REDEFINE 1 trial shows that cagrilintide alone achieved 11.5% weight loss at 68 weeks

Combining metabolic modulators with immune-regulating therapies represents a promising strategy for improving SLE treatment outcomes

Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months

Mechanism: B12 is a cofactor for blood cell production and energy-yielding metabolism