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Generally, doses range from 100 to 200 micrograms (mcg) per injection

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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, 101 thereby being roughly four times higher than those in normal rats