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Vitamin B12 blood levels and peripheral blood counts must be monitored initially at one month after the start of treatment with Nascobal Nasal Spray, and then at intervals of 3 to 6 months

ALDH is a marker for both normal stem cells and CSCs and is an intracellular enzyme that converts retinol into retinoic acid, and detoxifies the cellular system [59]

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Figure 2 Conclusion and Remaining Questions During past decade, investigation of ferroptosis from both aspects: induction and prevention, has become a topic of interests for numerous different pathologies

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Statements Acknowledgments Work in our laboratories is supported by ERDF-cofinanced grants from the Ministry of Science and Innovation (BIO2012-33904 and BFU2011-22779)