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A phase II trial aimed at assessing the clinical efficacy of aerosolized A1AT demonstrated a significant improvement in the time to the first pulmonary exacerbation and the total number of exacerbations

M., Weiskirchen, R., Breitkopf, K

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336 Although the Nrf2/HO-1 pathway has been shown to regulate iron storage and efflux through the transcription of genes like ferritin, FPN1, and hepcidin, 341,342 its specific role in PH, particularly concerning iron deficiency, remains unclear

Despite considerable efforts, inflammation currently remains one of the most complicated and difficult medical challenges in the world