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Quantitative real-time polymerase chain reaction (qRT-PCR) Using quantitative real-time PCR, the gene expression of phosphoinositide 3-kinase (PI3K), serine/threonine-protein kinase (AKT), mammalian target of rapamycin (mTOR), CDK4, CDK6, transforming growth factor- (TGF-), and nuclear factor-kappa (NF-) (Table 1) in cells was quantified