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Altschul et al

rosea possesses antioxidant and mitochondrial-protective properties, effectively scavenging reactive oxygen species (ROS), stabilizing mitochondrial membrane potential, and augmenting adenosine triphosphate (ATP) synthesis, which collectively uphold neuronal bioenergetics during conditions of physiological stress (57)

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This modification destabilized the protein in human cells but at the same time, increased its transactivation potential as judged from the luciferase assay results [55] (Figure 1B)