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[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Fitzpatrick AM

Acknowledgements The authors acknowledge Figdraw for assistance with figure creation

GPx-4 plays a crucial role in cellular defense against oxidative stress, primarily by reducing lipid hydroperoxides to their corresponding alcohols and converting free hydrogen peroxide into water, thereby preventing lipid peroxidation of cell membranes

Botany, traditional uses, phytochemistry, pharmacology and toxicology of Ilex pubescens Hook et Arn

Key scientific concepts Given its important role in cell metabolism, the ability to monitor and model the glutamine metabolic pathways are highlighted

Further, anticonvulsive drugs (e.g., Phenytoin) or hyperosmotic (e.g., Dexamethasone) therapy may be added to CaNa 2 EDTA infusion if needed