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Idiopathic Parkinsons disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients

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Beads containing bound and reduced Trx1 were resuspended in 6 mL 50 mM HEPES buffer (pH 7.5) and 500 L fractions were loaded on sealable micro gel filtration columns (ThermoFisher Scientific, #69705)

Additionally, SF demonstrated protective effects in rodent models of vascular cognitive impairment induced by ischemia at 56.4 mol/kg twice a week (112), subarachnoid hemorrhage at 282 mol/kg every 24 h (113), and intracerebral hemorrhage at 5.64 mol/kg twice a day (114), with upregulation of Nrf2 and reduced inflammation reported in the latter two

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Data are plotted as means with range of two biologically independent experiments