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A separate 2025 PubMed-reviewed paper on BPC-157 in orthopaedic sports medicine noted that the peptide showed positive outcomes in 87.5% of reviewed knee pain cases though the paper called out heterogeneity in study design and dosing protocols

Renal impairment affects not only the renal excretion of a drug but may also alter metabolism and active transport in the kidney, liver or gut and affect absorption, tissue distribution and plasma protein binding [13]

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