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While its efficacy in treating acetaminophen overdose, cystic fibrosis, and chronic obstructive pulmonary disease is well-established, emerging evidence suggests that NAC may also benefit a broader spectrum of illnesses due to its safety, simplicity, and affordability

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Riddiough GE, Christophi C, Jones RM, Muralidharan V, Perini MV

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In this regard, many antioxidant and detoxifying enzymes, such as GST, SOD, are regulated by neuroprotective NF-E2-related factor 2 (Nrf2), a transcription factor activated by oxidative stress and electrophilic molecules and whose relevance in many ocular diseases including glaucoma has been recently reviewed (Himori et al., 2013) or I/R injury (Wei Y